Avandia and the Risk of Fractures
Taking Avandia significantly raises the risk of bone fractures. A bone fracture is a special medical condition in which there is a break in the continuity of the bone. In view of the problem of correlation of taking Avandia and the risk of bone fractures, it should be said that fractures often result from certain medical conditions and the medications a patient receives on a regular basis can lead to broken bones. That is why after a year or two of use, Avandia can increase the risk of bone fractures. Doctors say that Rosiglitazone belongs to the group of medicines that interfere with the cells that grow new bones in our body. The fact is that in our body old bone cells are constantly being replaced by new cells. It is exactly this process that keeps our bones resistant to fractures.
Thiazolidinediones, a group of medications where Avandia refers to, inhibit the action of osteoblasts. Osteoblasts are cells responsible for bone formation. In our body they function alongside osteoclasts - bone cells involved in the process of bone resorption. Both osteoblasts and osteoclasts are responsible for controlling the amount of bone tissue. Avandia disrupts the precarious balance between osteoblasts and osteoclasts, and as a result a patient becomes more susceptible to bone fractures. That is why diabetes sufferers taking Avandia run a high risk of developing osteoporosis.
Another important outcome of using Avandia shows that women are twice as likely as men to suffer from bone fractures. Some signs have been noted which have given clear evidence that women taking Avandia usually appear at an increased risk of arm and hand fractures. So far no tests have detected increased hip or spine fractures.
Some of the trials of Avandia have shown the interconnection between the risk of fractures and a patient's age. These trials have demonstrated that the older a person is the more liable he / she is to fractures irrespective of gender.
To prevent fractures you either need to stop taking Avandia or you need to introduce lifestyle changes and sometimes medications. The simplest thing you can do is to start taking Calcium and Vitamin D which can be very helpful in restoring the balance between osteoblasts and osteoclasts.