Medical Encyclopedia

Diabetic therapy often admits of a combination of different medications all aimed at bringing blood glucose levels to normal and acceptable limits. The interaction of different agents can have different results.

One of the most typical interactions with Starlix is that of another glucose-decreasing medicine Metformin. This combination does not cause any relevant changes in the action of either of these agents. Unless such a combinational intake stimulates hypoglycemia, it produces the intended result and is therefore quite acceptable. The optimal combination is 120 mg of Starlix 3 times a day before meals and 500 mg of Metformin a day.

The combination of Starlix and Metformin also gives a noticeable reduction in the level of glycated hemoglobin. This reduction is greater than under either Starlix or Metformin monotherapy.

Besides, the combination of Starlix and Metformin results in weight balance. Starlix monotherapy may cause a slight weight increase, whereas in case of Starlix and Metformin combination no changes in a person's weight have been registered.

Another combination which has proved to bring positive results is that of Starlix and Rosiglitazone. This combination contributes to the normalization of glucose levels and also leads to the decrease in the glycated hemoglobin level.

It is of particular importance that when administering any drugs, not necessarily anti-diabetic agents, as well as withdrawing any of the medications a diabetic takes, it is significant to observe the patient closely for glycemic control to prevent hypoglycemia or sometimes hyperglycemia. That is why it makes perfect sense to discuss any combinations of drugs with your doctor, especially warfarin, tolbutamide and phenytoin. They are not known to produce any additional benefits when combined with Starlix, but they can trigger hypoglycemia unless the intake is closely monitored.